Many thanks for your reply; the delay was no problem.
It was much more helpful than the one I got from Remeha, which said that I could not use an iSense with an open vent boiler and I couldn't use a Honeywell CM9XX programmable stat either! I don't understand this as the Remeha wiring diagrams show Opentherm devices used with system boilers which, after all, is nothing more than a sealed system version of an OV boiler but with an internal pump. It also uses exactly the same PCB and the boiler type setting is the same.
I'm relieved that the iSense controls HW times/temperatures as I was going to have wiring problems if I had to retain the old HW timer. This is located upstairs in the airing cupboard with the valve and pump and running an additional cable to the boiler in the kitchen would have been a nightmare.
I have just been re-reading the topic about your Remeha 18S boiler and the iSense RF. I am thinking of doing the same and would be interested to know how you have got on with the system, particularly the iSense RF. Does it control the hot water times and temperatures or did you have to install a separate timer for the HW?