Wiser single channel is volt free, and can have an opentherm module, but the double and triple channel can only work at low voltage (230 volt) I personally think using the same back plate for all three is wrong, it is asking for problems, however it has been done like that for years, by many thermostat and programmer manufacturers not just Drayton.
The idea of using the same circuit for all 230 volt central heating items seems good, but a circuit is an assembly of electrical equipment supplied from the same origin and protected against overcurrent by the same protective device(s), so if there is a fuse inside the boiler, then to be the same circuit means it needs to be supplied from the boiler, however a supply, is what runs the whole house, so it will always be the same supply.
As
@ian1182 says "The intent is that the entire CH system can be isolated from a single location for safety purposes." but this is only really a problem when not using a volt free thermostat, the Nest thermostats are often supplied from a separate step down power supply, or USB module, but really there is no difference to if the power supply is integral or separate, if the contacts are volt free, it does not matter if supplied from same circuit or not. Only when using the non volt free is there a problem, one expects if you turn some thing off, then there is nothing live after that point.
The problem comes when volt free is replaced with non volt free, but one can't stop those who come after you not to do some thing daft.