If it's any use, I'll add my massively inexperienced perspective on this one.
I've got a combi boiler setup, and I've just repiped all of my downstairs rads in plastic - 22mm JG Speedfit, with pushfit reducing tees and 15mm pipe coming up under each rad. Compression fitting joins the upstairs pipe to the plastic. In short, the install was an absolute doddle - took me a morning to run most of the pipe, and probably a day's work to connect up the rads and test everything.
However, when I did a similar job upstairs, I did NOT use plastic - I used copper. There were three reasons why:
1. Would struggle to get plastic to bend through some of the tight spaces that copper has bent nice and neatly using a pipe bender
2. If the joints fail upstairs, I've flooded all my ceilings. If the joints fail downstairs, I've just got a damp concrete crawlspace to deal with.
3. I kept a lot of the existing pipework upstairs, and didn't like the idea of mixing plastic and copper so much.
So my thoughts would be if you're going to use plastic in a loft conversion, might be worth looking at using compression fittings so there's less chance of a fitting blowing off? At worst you'll get a slow leak which you can find and fix before it does too much damage.
PS - I think it's recommended a MINIMUM of 1m copper from the boiler unless your boiler manual says otherwise - but I've erred on the side of caution and used around 2m.
Russ