The radiator in the room with the thermostat installed should not have a TRV fitted. Otherwise the TRV can interfere with the correct operation of the room thermostat.
I don't agree with that due to bitter experience trying to get mother's central heating working. The idea places for the thermostat is in a room kept cool, with no alternative heating, on the lower floors, and no outside doors, in real terms such a room rarely exists.
So setting the TRV to approx same temperature as the wall thermostat when for example the room is the hall, will allow fast recovery when outside door has been opened but before it reaches the wall thermostat temperature it has closed so in winter the boiler never turns off, OK assuming gas, not quite the same with oil.
I used Nest Gen 3 as I only had two wires and wanted to control both DHW and CH plus charge the unit although in hind sight not the best option.
My major error was I thought the hall would cool down rapid, and it does not, heating time can be varied with the lock shield valve, it is cooling time which is important. At first glance it seems my thermostat is in the idea place, centre of ground floor, between doors for shower room, living room, kitchen, and dinning room, but being centre of house it cools down too slow, and no amount of adjusting on lock shield or TRV can correct that, so I get a hysteresis in living room as waiting for hall to cool.
Oil does have a combi version, but really a cheat, it is a storage tank built into the boiler, the boiler can't modulate it can only turn on/off. With modern gas however the boiler modulates (turns down output) so it should never turn off in the winter, unless there is a change in the temperature called for.
This is where the TRV and wall thermostat in same room gets complex, if the wall thermostat turns down at a set time, then once the room has cooled it will keep switching on/off unless a modulating thermostat is used or the TRV is also programmable.
My hall radiator is opposite end of hall to thermostat. So looking at my TRV now it shows target 17°C current 19°C, the Nest Gen 3 shows 19.5°C and set to 19°C it should change at 1:15 am in another ¼ hour. The TRV changed temperature at 10 pm, so nearly 3 hours and hall has not cooled.
Living room has two radiators one shows 19°C the other 20°C so near enough to what is wanted. The other programmable TRV heads only show target. It is so much easier with gas, the TRV controls the boiler output, the wall thermostat is only there to stop it cycling in the summer.
Hind sight, would have been better with a wall thermostat that linked to the TRV heads, well I thought it would, when I got Energenie mihome TRV heads it said they worked with Nest, but it seems when Google bought out Nest they also removed support for Energenie.
It seems at the moment
Drayton Wiser is the market leader, but uses wireless, main reason for Nest Gen 3 is it can use a pair of cables between the heat link and thermostat, and heat link is in flat below the main house so I was worried if the wifi would work through the floor.
There are others like EvoHome and Tado, all do a OpenTherm version if your boiler can take it.