If you don't want to keep anything there, spray it with Glyphosate. A couple of weeks later, spray it again.
I would then mulch heavily (six inches) and watch for any regrowth through the mulch (especially round the edges). Spray it again if there is any. Otherwise, plant things by pulling the mulch aside for the hole, and pulling the mulch back round the stem afterwards to cover exposed soil. Keep an eye out for weed growth and spray what you see. Very little will grow in or through a thick mulch,although your established plants will have their leaves above it so will be OK. You will then have to continue tending and weeding it in future years. If your neighbours have bindweed (Convulvulous) it will come under the fence, but Glyphosate will kill it
If you don't want mulch and plants, you can dig it over for a lawn. Spray weed growth before and after digging, and just before you sow the grass seed. Then, regular mowing will kill almost any weeds that try to come through the grass.
If you want a job for life that will never end, you can hand-pull weeds instead of spraying and mulching.