Certainly
When gas is burned, one of the products of combustion is water vapour/steam. In the traditional standard-efficiency boilers of 10+ yeasts ago, this water vapour and the heat within it was chucked out of the flue to warm the world up.
Modern boilers are able to condense this water out, removing the heat in the process and putting it into the heating system. However, they can only do this properly if certain conditions are met. A difference in temperature between the heating flow and return of 20°C is required, and the return needs to be below 53°C. If the temperature difference (known as Delta T or dT) is reduced or the return temperature is too high, condensing stops and the heat within the water vapour is lost out of the flue, increasing running costs
A heating system sized to run at low temperatures and the correct dT will condense (nearly) all of the time, requiring less gas to be burned to get the same heat output.
As Vulcan has suggested, high-efficiency controls such as those using the OpenTherm protocol will optimise boiler output to further increase efficiency