Just to add to my previous coments,
I'm my experience aerated blocks (Thermalites) are very prone to cracking and they don't seem to stick together very well when using standard mortar, I know this as the inner leaf of my extension has been built with them, given my time over again there is no way I would have used them and would have went with concrete blocks for a much sounder job.
You could use concrete blocks on the outer leaf and if you must aerated blocks on the inner. The one thing I would say however is that if you intend for the inner blocks to be rendered and plaster skimmed any cracks in them may extend through the plaster. I've read that plasters put expanded metal laths over the aerated blocks so the cracks don't come through.
Regarding U values, I don't know a lot about this subject, I have a 75mm full fill cavity, this is with a brick outer leaf and a Thermalite inner, the walls are going to be boarded, I'm not sure if using concrete blocks for the inner leaf would have made much if any difference to the cavity required.
My honest advice to anyone considering using aerated blocks would be to try their best not to as I can only describe them as rubbish, yes on paper they may give a better U value than concrete blocks but I wonder if that still stands when they have cracks in them! I can fully understand why some builders refuse to use them and will only use concrete blocks, if I were in business I would do exactly the same.
Cheers.