Of course they go whether you use them or not, the O2 cells deteriorate continuously even if you don't use them. Did you think the oxygen stops corroding if you don't use something?if you rarely use it will it still go-out-of-true?
There is ample documentation available on the subject on the web.If so - how? Give us the science.
If you google long and hard enough, you may even find something that is dumbed down to such a degree that even you can understand it.