That's quite encouraging. I'd heard of it cos I have a 2nd nephew who's working on non iconoclastic cancer treatments, though his are phagocytic. There's a swarm of methods being tried.
It's fascinating; you extract DNA from the tumour, sequence it to find the mutations, then design mRNA that codes for pieces of those mutant proteins. Those, are put into nanoparticle fat bubbles and injected in to the patient's muscles. The muscle cells read the mRNA and make more of the cancer protein fragments, which are "visible" to be discovered by the body's immune system, without beng dangerous themselves. So T cells get taught to attack the actual cancer because it looks like those fragments. So the muscle is just a handy factory to make bits the T cells react to .
It's like the covid vaccine, where the muscle cells read the mRNA and made copies of the spike protein, which was the one the real virus used to get into cells. . The immune system saw the spike proteins and configured loads of immune cells to attack it.
MOnoclonal antibody cancer treatments have about 3 means of working, to hit specific cancer types, but none of them have been particularly effective for pancreatic cancer. This mRNA approach uses a vaccine engineered to attack the a specific cancer active in the individual patient.
