I reckon you can over-analyse. Despite my engineering design background I didn't bugger about with maths at all, I used HeatPunk (free!), you just draw your house, tell it what each wall is composed of then it helps you to find the right radiator sizes. You can then play games with flow temperature vs radiator size.
I've ended up with a design that's tolerable from an aesthetic angle that will theoretically heat the place adequately at a flow temperature of 42 degC.
I'm going to keep quiet about all this homework when I start talking to plumbers soon. I don't want to be the nightmare smartarse customer, but I will quietly compare their design with mine. Unless they come up with something better of course.
I'm just going to install the thing and see what happens. The zone valves will be installed but all manually locked open. Then I can start manually closing them and see what happens. I'm also bench-testing timer/thermostats for each of the zones in parallel. Hopefully I'll arrive at a point where I have a good plumbing system and controls I'm happy will do the job, then I just need to wire them in.
I promise to post my findings!