You say your system is free of air, but how can you be sure.
You may have bled the radiators and the pump, but that does not cover the whole of the pipe work.
Imagine filling your pipe work. Water comes down from a tank to a 'tee' to fill the system. But the circuit of pipes starts and finishes at that 'tee' so water flows in both directions. Agreed air gets pushed into radiators where in can be bled off, but pockets of air can get trapped between radiators forming an 'air lock'. The pump tries to push the water and air along to radiators but sometimes fails because the air pocket is too big and just compresses. It would take ages to bleed off the water to release an 'air lock' via the radiators.
I believe the best way is by removing a upstairs radiator and running off some water from both the flow side and the return side.(system off)
This way, the resistance has been removed and any air released.
You can then check the system, before replacing the radiator.
If there is no 'air lock' the other options are, valves closed or blocked.
Pipe work flowing to or returning from radiators blocked with sludge, so running off water as suggested will help to identify.