Planning a tiled floor with patterned tiles

[meanwhileinhell]

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• meanwhileinhell
• 2 Apr 2015
• 2

I am tiling my bathroom (plan attached, floor area in blue) and using these tiles for the floor:
https://s-media-cache-ak0.pinimg.com/236x/43/ed/e5/43ede5d28bb99f1aaab09306b4a36be6.jpg

The tiles are 20cm square x 1cm thick. Do I need to plan these differently when working out where each tile will lie because of the type of pattern, or would these be laid the same as any other plain floor tile?

The manufacturer documentation is here, Planning section is page 6, I just want to make sure that this is the actual way these would be laid in practice:
http://www.firedearth.com/media/static/pdf/porcelain_tiling_guide.pdf

Also, do I need to consider where the toilet and sink will sit on the tile to ensure that a tile (or grout line) is central to the bottom of the toilet/sink pedestal?

Thanks a lot!