Different manufacturers put them, in different order.
All have a cold mains supply for the domestic hot water and a domestic hot water both in 15mm. Usually there is a sloted ball isolation valve on the cold.
There is a flow and a return pipe, usually with isolators in 22mm. Sometimes next to each other sometimes at oposite sides.
Gas pipe often right in the middle, usually 22mm some are reduced to 15mm. just under the boiler, bad installations are 15mm all the way. Usually has a yellow isolation valve on it, doesn't have to be yellow, does have to have an isolator.
Filling loop is t'd into the return pipe, and gets it's water from the cold pipe. There is a double check valve where it joins the return pipe sometimes incorporating isolator, and always an isolator at the cold supply end.
There is a 15mm pipe going out through the wall from a red buttoned pressure relief valve set to go off at 3 bar.
Some systems have a bipass, usually out of site which goes between flow and return, should be automatic these days, older ones have a manual valve on them. Many manufacturers were forced to put a small bipass pipe within the combi because of failures due to lack of bipass in the instilation when required.
Present day boilers have a condensate drain, usually 3/4 in overflow pipe, can be 32mm or 41mm waste pipe.