Indeed, as you say, if one measures intra-cellularly, or even on the surface of a cell, depolarisation potentials/ 'action potentials' in nerve and muscle cells are relatively 'large' - the resting potential across those cell membrane is around 70mV, so the changes one sees on depolarisation are at least that large. However, when one has an interest in what happens at, say, neuro-muscular junctions, one may wish to look at the ('sub-depolarising') changes in membrane potentials resulting from the release of single 'packets' of chemical transmitters, and those potentials can be well under 1mV, even when measured locally.Probably the same aggravation while trying to sense (and amplify) tiny biological signals from "nudging molecules" or even intra/extracellular potentials formed during nerve depolarisation though I expect (but am not sure) that peripheral nerve depolarisation potentials (and resultant signals) are quite large compared to say signals in nerve axons of the brain or inter-molecular signals?
In clinical applications, of course, one is usually measuring 'at a distance' (e.g. ECGs and EEGs) i.e. looking at the field created within the conductive human/animal body created by the distant 70mV+ cellular potentials. As a result, surface-measured ECGs are of the order of 1mV and surface-measured EEGs as low as 10uV. In contrast, 50Hz and 'Radio 2' picked up by a human body can be orders of magnitude larger - and one has to rely on a mixture of low-pass filtering, 50Hz band-stop filtering and the common-mode rejection of differential amplifiers to get rid of most of that ... but then, to take one back to where we started, the amplifier then has to be somehow protected from picking up Radio 2 (and all sorts of other things) itself.
Kind Regards, John.
