I spent a year doing nothing else but fitting alarms to BT building and every one had a fuse in the main 48 volt DC distribution board. Clearly it will change installation to installation and manufacturer to manufacturer and there will be no single answer to the question.
However as pointed out most require a point of isolation and isolation requirements vary with the supply type. With a TT supply likely you will require a switched FCU to be able to isolate but with a TN supply a un-switched FCU or single pole MCB would be fine to isolate.
The point is both line and neutral are considered as live conductors.
537.1.2 Combined protective and neutral (PEN) conductors shall not be isolated or switched except as permitted by Regulation 543.3.4.
Except as required by Regulation 537.1.4, in a TN-S or TN-C-S system the neutral conductor need not be isolated or switched where it can be regarded as being reliably connected to Earth by a suitably low impedance. For supplies which are provided in accordance with the Electricity Safety, Quality and Continuity Regulations 2002, the supply neutral conductor (PEN or N) is considered to be connected to Earth by a suitably low impedance.
I would think that most manufacturers do not want to include this in their instructions and it is simpler just to say isolation is required which with a TT system would not be provided by simple removal of the fuse or switching a single pole MCB.
The fuse holder of the standard FCU can take a lock through it locking it off but with the MCB normally some device is required to be able to lock off the MCB. In commercial often the doors to the distribution units can be locked shut as well as using the special clips to attach locks to individual MCBs.
On a personal basis if the supply is TN and there is a clip provided to lock off the MCB then it should comply. With a TT system then a switched FCU would be required with an ability to attach a lock to the switch. Using a keyed double pole switch like used with emergency lights maybe a better way to provide isolation. It could also have a fuse but if fed from a dedicated MCB can't really see the point.
So to recap the main point is what is the supply type. With a TT that's with an earth rod then you need an isolator with a TN that's where the supply company supply the earth then not really required.
Being pedantic if the manufacturer says it needs a switched FCU then you should use one to comply with rules. But with common sense with a TN system not really required.