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As above theoretically you can have 600mm centres for plasterboard so one down the middle would be ok, that's how they set out trussed roofs, but 400 centres would be more resistant to sagging.
I would use packers either cut with a chop saw or the ones for windows between the timbers and the ceiling in order to take out the worst of the out of level. If you really want some precision you can resort to folding wedges but that would only apply if you have laser vision like superman
Also think about how you're going to get it up there, i managed a similar size room on my own in two pieces but if you're using one piece think about logistics getting the board in place with you and lifting all that weight and screwing it in. Full size Shower panels i struggled and that was with only having studded out half the room so i could get them in easily.
I would use packers either cut with a chop saw or the ones for windows between the timbers and the ceiling in order to take out the worst of the out of level. If you really want some precision you can resort to folding wedges but that would only apply if you have laser vision like superman
Also think about how you're going to get it up there, i managed a similar size room on my own in two pieces but if you're using one piece think about logistics getting the board in place with you and lifting all that weight and screwing it in. Full size Shower panels i struggled and that was with only having studded out half the room so i could get them in easily.