Most of it gets replaced every few years - all the blood cells for example. Apart from the obvious bits, nails hair etc, go and teeth ...
Some nerve & brain cells aren't replaced, eg when they're gone you can't remember stuff. Sperm only live a few days, which begs a couple of questions...
Replication isn't perfect for various reasons, famously in copying the dna - first stage of mitosis, and that, which are part of degradation of aging.