There isn't a right answer to that
Normally there is a gas boiler involved, these days a condensing one. For those, you want to keep the return below about (IIRC) 54˚ so it will always be condensing - but to get the store hot this does mean restricting the flow a bit and running them with a higher delta-T than the manufacturer specifies. In your case there's no such restrictions, and until you reach the upper setpoint limit on the boiler there isn't really any restriction.
So, from the point of view of storing the most useful heat, this is what I believe you need to think about :
1) The hotter the better. Obviously, the hotter the water, the more energy stored in it. There are some constraints (upper limit on boiler for example), and the downside is that the hotter the store, the higher the standing losses. Losses (ie the heat that leaks out of the store) can be minimised by insulation, and as long as the store is within the heated area of the building then the losses aren't really lost - except in hot wether then you'd prefer no heating.
So you may well want to adjust the system for the changing seasons. For the same reason, some people have several thermostats (or sets of stats) and switch between them - heating the full tank in winter, and only the top in summer when they are using little heating and less hot water.
2) Stratification is important.
If you can keep everything stratified then you can take more useful heat out of the system. ie, you can keep drawing off the hot water, and the returned cold water will push it upwards. In an idealised setup, you'd be able to draw off all the hot water at whatever you heated it to in 1) above, and end up with a tank full of cold water. In practice it's not as ideal as this.
On the other hand, if you don't design the system right and mix all the water up, then you cool the whole tank and end up with a tankful of tepid water that's not hot enough to be useful. This could cut the amount of available heat by half (or worse).
Also, if you keep things stratified, then your reheat is more effective. If you have run the store right down, then as you put hot water in at the top, you don't need much before you have useful heat available - once you've got hot water in the top of the store, then you can draw it off and use it. If you heat "bottom up" then you end up having to heat all the water in the store before you can draw off anything useful.