2 wire system as I know them are conventional fire alarm systems which has the sounders wired onto the zone (Savwire)
If this is what your planning then you'd simply wire from the control panel in and out of each device, when you reach the end of the circuit a End Of Line resistor will be fitted (supplied with panel)
Remember you need to get the in's and out's round the correct way else removing a detector head could leave the rest of the system not working
If your planning an addressable system then yes the sounders can be wired onto the loop but this isn't what I'd call a 2 wire system
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