Plastic spacers are used a for a lot of things, just not for laminate floors. I cheat and just put 2" lengths of the cork about every foot, especially along the straight sections. Are you taking the skirting boards off, or adding quadrant to the bottom of the skirting boards after the laminate is down. In some ways, it's maybe not a relevant question. You tend to decide which way you want the laminate to go, and then start putting it down, the last piece you cut off, becomes the start of the next row, assuming it's at least half of a board length.
Ideally, you're last row will be more than half of a board width, and if it'snot going to be, calculate the last board length if you start on the other wall. What's the size of your room, and the dimensions of your boards.