I've got a bit of a cold at the moment and noticed this morning some of the survey details I entered from the survey sheet on the app have not been transposed correctly to the report that I have access to. It may be a fuzzy me yesterday evening, it may be because I see my status at Heat Engineer has changed to a demo version for educational purposes now which may mean there have been other anomalies (I was granted free use to demo to course attendees at our centre and webinars). Heat Engineer is a charged for facility, and rightly so, it is so good.
Some of the rooms have heat requirements oversized to what I would expect so I'd be inclined to drop that figure. It would drop anyway with continual heating at comfort and setback temperatures.
Hot water I would not add as I'd suggest to a customer they use priority domestic hot water with a condensing boiler as it improves efficiency in space heating mode. Sored hot water is reheated with a fast recovery cylinder using the whole output of the boiler at high non-condensing temperatures in a short space of time then space heating resumes at low temperatures in condensing mode. Over 80% of your energy bill will be space heating, DHW is comparatively small so maximize low temperature operation.
With regard to pump. If you want to maximize efficiency in all areas one thing is to operate the system with a wide ΔT across the system and boiler. An optimal ΔT of 20°C means a fair bit of balancing and matching pump performance. Some of the boilers at high output you may be considering can have very little residual head after losses within the boiler exchanger have been overcome, even those with 7m and 7.5 metre head pumps meaning use of an additional pump.
You may be looking at 1200l/hr if you operate at ΔT 20 which will leave little head on the pump with some boilers (on our system boiler just under 3.5m head at that flow rate) and you have a large system. Unless pipe sizing is carried out to keep head loss down, which is perfectly possible, there may be problems and I don't know how the pipework is run or sizing. It would be doable on some with the boiler pump possibly not with others.