All radiators in one zone are parallel, so there is no real first or last.I can see one glaring error to start with. The return from the hot water cylinder must be the last tee before the boiler; it must come after all radiator return tees.
The dhw circuit runs as a separate zone parallel to the ch zone/circuit.
Assuming for the moment that 21st century controls are used allowing independent settings, they would not even be on at the same time under normal circumstances.
Even if ch and dhw were on at the same time, the resistance over dhw zone is around 10 times lower than your average radiator and as such will have a much larger "drain" and thus still absorb much more heat than any radiator even if the cylinder was piped up as another radiator in the heating circuit.