Longer answer: not in terms of power consumption, I don’t know about the difference in bulb life and bulb costs?
The answer you didn’t ask for: if your thinking about costs then your looking at the wrong lights, 300W of power is a lot to use to light a room even if it’s a big room that needs that much light you can get just as much light with a lot less power from CFL’s. there are CFL’s that fit in downlighters but the one I have seen stick out, you may now be able to get downlighters designed for CFL’s but personally I am not a fan of downlighters for the many reasons I listed in the wiki
They will cost pretty much the same to run (the transformers are not 100% efficient though and there will be some losses).
However, assuming they are tungsten halogen then 12V ones will give you more light.
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