As far as I am aware the Worcester Bosch boilers have never adopted opentherm they have with some models an ebus control option, however this means control is one area only. So in the main Worcester Bosch boilers have a simple on/off control for the electric side, all the real control is done on the water side by monitoring the return water temperature, so nearly any wall thermostat will work, even ones like Nest with opentherm still have the on/off option.
So the big question is will one thermostat with no link to TRV heads do what you want? I fitted Nest Gen 3 as I wanted hard wired install and Nest allowed this with my system, and at the time of install I thought Nest would work with the Energenie MiHome TRV heads I already had, however it seems Nest has withdrawn support.
I will admit the Nest geofencing seems to work well, but the learning feature does not seem to learn what the programmable TRV heads are programmed to do, not that we can really expect it to, so you have to consider what is the best control for your way of life and your house, if your going to install Nest then stop, likely Nest will work well, but if you want to add programmable TRV heads, then the first job is look at what programmable TRV head you want to go for.
So super cheap eQ-3 at £10 does not connect to any wall thermostat so does not matter which you have, same with Terrier i30.
Then there is a big jump in price, the Energenie MiHome I have seem to work the wrong way around, the wall thermostat controls the TRV if linked and the whole idea is not to have every room at same temperature.
The rest the TRV tells the wall thermostat what to do, EvoHome has a nice central hub from where you can control all, Drayton have Smart TRV's that work out time to heat a room, Hive is another odd one, the TRV sends a demand for heat to the wall thermostat which turns the wall thermostat on for ½ hour.
However you need to consider what in fullness of time is your aim, and select the product which will not only do what you want now, but also will still do what you want in 5 years time. I admit it does not always work, I selected Energenie MiHome TRV heads with the idea of adding Nest latter, and when I got Nest found support had been dropped. I also told loads not to buy Hive as it was not really "Smart" and did not work with TRV heads, then they released a range of heads, so now still not really "Smart" but it does do a lot more than it did.
Reading reviews it seems Hive has had problems with the wireless linking, and have released a more powerful hub, but as to if because some houses use a insulating plaster board which turns the rooms into Faraday cages, or if original not powerful enough I don't know.
It seems no good asking heating guys, as they don't live in the houses, so they don't know how well each geofencing works, or how good the algorithms are, we just stick in a pin. And in the main owners do not want to admit when they get it wrong. And even when they do, never sure if really something wrong or some thing they did.
In Mothers house with Worcester Bosch combi gas boiler the Energenie MiHome TRV heads after a few teething problems worked well, this house with Worcester Bosch oil system boiler they have not worked as well, however since we took them with us from last house, we have never tried to live in this house with non programmable TRV heads. So could be house design.